The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles

Key Points

• The aim is to investigate how bioisostere substitution affects the properties of supramolecular self-associating amphiphiles.
• Examined different bioisostere substitutions in amphiphiles
• Measured antimicrobial activity against various microorganisms
• Analyzed physicochemical properties of the modified amphiphiles
• Bioisostere substitutions significantly improved antimicrobial activity
• Some substituted amphiphiles exhibited enhanced solubility and stability
• Results highlight the potential for developing more effective antimicrobial agents