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January 1, 2026RSC Medicinal ChemistryOpen Access

The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles

Pinky K. Naicker M. Yacoub Lisa J. White Dominick E. Balderston Perry A. Hailey J. Mark Sutton Charlotte K. Hind Jennifer R. Hiscock

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Key Points

The aim is to investigate how bioisostere substitution affects the properties of supramolecular self-associating amphiphiles.
Examined different bioisostere substitutions in amphiphiles
Measured antimicrobial activity against various microorganisms
Analyzed physicochemical properties of the modified amphiphiles
Bioisostere substitutions significantly improved antimicrobial activity
Some substituted amphiphiles exhibited enhanced solubility and stability
Results highlight the potential for developing more effective antimicrobial agents

Implication

Demonstrates enhanced antimicrobial activity in amphiphiles using bioisosteres, indicating greater effectiveness.

Abstract

The use of bioisosteres enhances the antimicrobial activity for a range of supramolecular self-associating amphiphiles.

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Cite This Study

Naicker et al. (2026) studied this question.

synapsesocial.com/papers/69c37afeb34aaaeb1a67d0ea https://doi.org/10.1039/d6md00091f

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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5Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic PeptidesIn Vitro Study · 2026 · 3 citations

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