What question did this study set out to answer?

The aim was to identify predictors of reamputation risk and mortality in patients with diabetes undergoing lower limb amputation, specifically focusing on antidiabetic medications.

March 25, 2026Cardiovascular DiabetologyOpen Access

Reamputation risk and mortality after lower-limb amputation in patients with diabetes: predictors, effects of antidiabetic medications and temporal trends

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The aim was to identify predictors of reamputation risk and mortality in patients with diabetes undergoing lower limb amputation, specifically focusing on antidiabetic medications.
Analyzed data from 607 patients with diabetes and 500 without diabetes undergoing non-traumatic lower limb amputation between 2006 and 2022.
Assessed reamputation-free survival as the primary endpoint.
Used Cox regression and joint frailty models to analyze predictors of reamputation and mortality.
Diabetes increased the combined risk of reamputation and mortality (HR 1.28).
Higher HbA1c levels were linked to lower reamputation-free survival.
Metformin significantly reduced the combined risk of reamputation and mortality (HR 0.59).
SGLT2i usage showed increased reamputation risk (HR 2.00) but safety concerning mortality.
Reamputation risk peaked between 2020 and 2022, while overall mortality declined compared to 2006-2010.

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Implication

Observational study investigates reamputation risk and mortality in diabetes, highlighting medication effects and trends.

Cite This Study

Radlinger et al. (2026) studied this question.

synapsesocial.com/papers/69c37b20b34aaaeb1a67d3ca https://doi.org/10.1186/s12933-026-03145-9

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Reamputation risk and mortality after lower-limb amputation in patients with diabetes: predictors, effects of antidiabetic medications and temporal trends

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Implication

Cite This Study

Reamputation risk and mortality after lower-limb amputation in patients with diabetes: predictors, effects of antidiabetic medications and temporal trends

Key Points

Discussion

Implication

Cite This Study

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