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March 25, 2026Journal of Medical MicrobiologyOpen Access

Functional and molecular characterization of Aspergillus fumigatus phosphoglucomutase (Pgm): a potential target for antifungal therapy

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Authors

CAConrad Chibunna AchilonuTKTheodore J. KottomALAndrew H. Limper

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Overview

Demonstrates the role of Af PGM in fungal growth and cell wall formation, suggesting its potential as an antifungal target.

Key Points

  • The aim is to investigate the functional role of Af PGM in carbohydrate metabolism and its implications for antifungal therapy.
  • Used a conditional A. fumigatus P alcA::pgm mutant for growth and biofilm assessment.
  • Evaluated functional complementation through heterologous expression in a S. cerevisiae pgm2Δ strain.
  • Examined enzymatic inhibition with the isothiazolone compound ISFP10.
  • Reduced Af PGM activity led to impaired growth and altered cell wall-related characteristics.
  • Decreased soluble β-glucan levels and reduced biofilm biomass were observed.
  • Functional expression of Afpgm restored growth in the yeast mutant to wild-type levels.
  • ISFP10 successfully inhibited Af PGM activity and disrupted fungal phenotypes.

Cite This Study

Achilonu et al. (2026) studied this question.

synapsesocial.com/papers/69c37b54b34aaaeb1a67da83https://doi.org/10.1099/jmm.0.002140
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Also Consider

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