What question did this study set out to answer?

This research aims to explore the relationship between immune priming and the risk of viral acute respiratory infections (ARIs).

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March 25, 2026Open Access

Immune Priming and the Risk of COVID‐19, Influenza, and Other Acute Respiratory Infections: Insights From an N3C Cohort

Key Points

This research aims to explore the relationship between immune priming and the risk of viral acute respiratory infections (ARIs).
Analyzed electronic health records from the N3C cohort.
Assessed associations between immune priming and infection outcomes.
Considered potential biases in data collection and healthcare-seeking behavior.
Identified potential crossprotection between COVID‐19 and influenza.
Found that some negative associations indicate a protective effect.
Highlighted the need for further investigation into public health strategies.

Abstract

This exploratory analysis suggests potential crossprotection between viral ARIs that may inform vaccination strategies. While ascertainment and healthcare-seeking biases in electronic health records may inflate positive associations between infection outcomes and immune priming, negative (i.e., protective) associations are of potential public health significance and warrant further investigation.

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Cite This Study

León et al. (Sun,) studied this question.

synapsesocial.com/papers/69c37b62b34aaaeb1a67dc3a https://doi.org/https://doi.org/10.1111/irv.70253

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