Comparison of Oral Cephalosporin and Penicillin Step-Down Therapy for the Treatment of Gram-Negative Blood Stream Infections: A Retrospective Observational Study | Synapse
March 25, 2026
Comparison of Oral Cephalosporin and Penicillin Step-Down Therapy for the Treatment of Gram-Negative Blood Stream Infections: A Retrospective Observational Study
Key Points
To compare the effectiveness of oral cephalosporins and penicillins as step-down therapy for treating gram-negative bloodstream infections caused by Enterobacterales.
Conducted a retrospective observational study
Compared outcomes of patients receiving oral cephalosporins and those receiving oral penicillins
Analyzed clinical effectiveness in treating gram-negative bloodstream infections
Oral cephalosporins showed noninferiority compared to oral penicillins
Both therapies were effective for Enterobacterales bloodstream infections
This was the first study to compare these oral beta-lactams for this condition
Abstract
Oral cephalosporins were noninferior to oral penicillins as step-down therapy for Enterobacterales GNBSI. This represents the first comparison of oral beta-lactams for the treatment of GNBSI.