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March 25, 2026International Journal of Molecular SciencesOpen Access

The Role of the TG2-GPR56 Complex in Cutaneous Squamous Cell Carcinoma (CSCC) Aggression and Therapeutic Resistance

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Authors

DWDavid R. WeberMCMary E. CookWYWenbo Yu

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Overview

Review examines TG2-GPR56 interaction driving aggression and therapy resistance in CSCC, highlighting its implications.

Key Points

  • This review aims to explore the molecular interactions of TG2 and GPR56 in enhancing the aggressiveness of cutaneous squamous cell carcinoma.
  • Comprehensive review of existing literature on TG2 and GPR56 interactions in cSCC.
  • Analysis of clinical data regarding aggressive cSCC cases and their metastasis rates.
  • Examination of in vitro keratinocyte models to understand the mechanisms of tumor invasion and therapy resistance.
  • The TG2-GPR56 complex significantly correlates with the aggressive phenotype of cSCC.
  • Evidence suggests this molecular axis maintains epidermal cancer stem cells crucial for tumor progression.
  • Postoperative recurrence rates in high-risk cSCC cases are approximately 5%, indicating therapy resistance.

Cite This Study

Weber et al. (2026) studied this question.

synapsesocial.com/papers/69c37b74b34aaaeb1a67dddfhttps://doi.org/10.3390/ijms27062902
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