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March 25, 2026Microorganisms0 citationsOpen Access

Rapid Antimicrobial Susceptibility Testing Using Urine Samples in 2 Hours

A Proof-of-Concept of a 2-Hours Direct Antimicrobial Susceptibility Test from Inoculated Urine Samples

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Authors

MSMariana Sousa-PinheiroIMInês Martins-OliveiraDADavid Brusaca Abreu

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Overview

A proof-of-concept study demonstrates faster antimicrobial susceptibility testing, supporting better UTI management and antimicrobial stewardship.

Key Points

  • This research aims to evaluate a rapid method for antimicrobial susceptibility testing directly from urine samples.
  • Analyzed 154 inoculated urine samples using FASTinov® panels for Gram-negative and Gram-positive bacteria.
  • Employed flow cytometry for rapid phenotypic antimicrobial susceptibility testing.
  • Evaluated performance against conventional methods based on EUCAST guidelines.
  • Achieved 97.5% agreement for Gram-negative and 95.0% for Gram-positive bacteria compared to conventional methods.
  • Identified all resistance mechanisms correctly without false positives.
  • Showed 95.2% essential agreement for vancomycin's MIC with a BIAS of +14.3%.
  • Demonstrated reproducibility rates of 99.5% for FASTgramneg and 95.0% for FASTgrampos.

Cite This Study

Sousa-Pinheiro et al. (2026) studied this question.

synapsesocial.com/papers/69c37b74b34aaaeb1a67de94https://doi.org/10.3390/microorganisms14030711
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