Develops a photocatalytic reaction to form new compounds from vinyl aziridines and alkyl halides, suggesting a novel synthetic approach.
Herein, we develop a photocatalytic [4 + 1] annulation of vinyl aziridines with alkyl halides. The reaction appears to experience radical trigger kinetically favored β-scission of the vinyl aziridine C-N bond, generating transient nitrogen-centered radical, followed by sequential single electron oxidation, 5-exo-trig cyclization, and protonation. Significantly, an unprecedented annulation mode in which vinyl aziridines serve as four-atom synthons has been disclosed.
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Wang et al. (2026) studied this question.
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