This research demonstrates photocatalytic amination of arenes using an isoquinolinium photooxidant, highlighting its potential applications.
We herein report a potent photocatalytic system for arene C-H amination utilizing an isoquinolinium photooxidant. The key to the process involves in situ protonation of neutral isoquinoline precatalyst IQ1. Resulting isoquinolinium IQ1•H+ exhibits a high excited-state reduction potential (+2.33 V vs SCE), enabling single-electron-transfer oxidation of inert arenes. The optimized reaction system demonstrates a broad scope, including electronically neutral arenes and various pharmaceutical small molecules with azoles and pyridines.
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Wakabayashi et al. (2026) studied this question.
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