Commentary discusses risk-based screening protocols, linking genetic testing to breast cancer outcomes.
Risk-based screening includes varying screening protocols for women based on their risk of breast cancer. The WISDOM trial incorporates universal genetic testing for nine susceptibility genes into risk assessment. Carriers of high-penetrance mutations are offered an annual MRI. One-third of the women with a mutation would not have qualified for genetic testing based on traditional criteria.
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Steven A. Narod (2026) studied this question.
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