What question did this study set out to answer?

The research aims to assess the safety of childhood vaccines and identify factors associated with adverse events following immunisation.

March 25, 2026BMJ Paediatrics OpenOpen Access

Understanding adverse events following immunisation: evidence of vaccine safety and coincidental events from 3 years of surveillance

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Cohort event monitoring evaluates vaccine safety and adverse events in children, suggesting vigilant public health responses are necessary.

The research aims to assess the safety of childhood vaccines and identify factors associated with adverse events following immunisation.
Conducted a cohort event monitoring study targeting children receiving vaccines under the Universal Immunisation Programme.
Utilized active surveillance through telephone follow-ups and passive surveillance from healthcare workers.
Evaluated predictors of adverse events using the χ2 test and calculated relative risk.
Estimated an AEFI incidence rate of 10.37%, with serious reactions at 3.47%.
The Pentavac vaccine had the highest incidence rate at 19.21% (218 events/1000 doses).
The oral polio vaccine had the lowest incidence at 0.13% (1.32 events/1000 doses).
Fever was the most reported reaction at 23.75 events/1000 doses, followed by pain at the injection site.
90.62% of reactions were vaccine-related, with few deemed coincidental.

Mathew et al. (2026) studied this question.

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March 25, 2026BMJ Paediatrics OpenOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Cohort event monitoring evaluates vaccine safety and adverse events in children, suggesting vigilant public health responses are necessary.

The research aims to assess the safety of childhood vaccines and identify factors associated with adverse events following immunisation.
Conducted a cohort event monitoring study targeting children receiving vaccines under the Universal Immunisation Programme.
Utilized active surveillance through telephone follow-ups and passive surveillance from healthcare workers.
Evaluated predictors of adverse events using the χ2 test and calculated relative risk.
Estimated an AEFI incidence rate of 10.37%, with serious reactions at 3.47%.
The Pentavac vaccine had the highest incidence rate at 19.21% (218 events/1000 doses).
The oral polio vaccine had the lowest incidence at 0.13% (1.32 events/1000 doses).
Fever was the most reported reaction at 23.75 events/1000 doses, followed by pain at the injection site.
90.62% of reactions were vaccine-related, with few deemed coincidental.

Mathew et al. (2026) studied this question.

View Full Paper

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