Subsets of Lupus Patients Identified by Gene Expression Profiles Exhibit Differential Clinical Responsiveness to Baricitinib

Key Points

• The research aims to identify specific subsets of lupus patients based on their gene expression profiles and their response to baricitinib treatment.
• Conducted transcriptomic analysis of SLE patient samples
• Identified gene expression profiles grouping patients
• Evaluated clinical responsiveness to baricitinib in identified subsets
• Distinct subsets of SLE patients were identified based on gene expression profiles
• Certain subsets showed improved clinical responsiveness to baricitinib treatment