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March 23, 2026Postgraduate Medical Journal

Host-microbiota interactions: a novel insight into the aryl hydrocarbon receptor in Parkinson’s disease

Ting Yu Hong Fan

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Key Points

The aim is to explore the relationship between the AHR-gut microbiota axis and the pathogenesis of Parkinson's disease.
Review of clinical and preclinical studies examining AHR and gut microbiota in PD.
Synthesis of existing evidence on AHR's role in PD pathogenesis.
Discussion of potential pharmacological interventions targeting the AHR-gut microbiota axis.
Evidence indicates a link between AHR activity and gut microbiota composition in PD.
Pharmacological targeting of the AHR-gut microbiota axis shows promise as a therapeutic strategy for PD.

Implication

This review synthesizes evidence linking the AHR-gut microbiota axis to Parkinson’s disease, suggesting therapeutic potential.

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69c37be2b34aaaeb1a67ec65 https://doi.org/10.1093/postmj/qgag017

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Emerging links between gut dysbiosis, aryl hydrocarbon receptor activation, and Parkinson’s diseaseReview · 2026
2Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson’s Disease—A Narrative Review2024 · 31 citations
3Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease2024 · 13 citations
4The role of gut microbiota in the pathogenesis of Parkinson’s disease: mechanisms of influence and therapeutic perspectives (review)2025
5Microbiome-Gut-Brain Axis: A New Perspective on Parkinson’s Disease2025

More related papers

The Gut Microbiota in Parkinson’s Disease: Mechanistic Insights into Microbial–Host Interactions2026
Narrative Review: Gut Microbiota and Its Impact on α‐syn Function in Parkinson's Disease2025
Exploratory gut microbiota-host interaction in parkinson’s disease: integrative multi-omics analysis of metabolic and epigenetic pathways2026

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