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March 25, 2026Diabetes Metabolic Syndrome and ObesityOpen Access

Cardiovascular Outcomes and Safety of GLP-1 Receptor Agonists in Elderly Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

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Authors

WGWeifei GaoXCXiaoming CaiXWX. D. Wang

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Overview

Systematic review reveals GLP-1 receptor agonists reduce cardiovascular events in elderly patients, highlighting important safety concerns.

Key Points

  • This systematic review aims to evaluate the cardiovascular outcomes and safety of GLP-1 receptor agonists in elderly patients with type 2 diabetes.
  • Conducted a systematic review of PubMed, Embase, and Web of Science
  • Included randomized controlled trials comparing GLP-1 RAs to placebo in patients aged ≥ 65 years
  • Analyzed cardiovascular outcomes as primary endpoints, alongside safety outcomes
  • Pooled risk ratios using a random-effects model
  • GLP-1 RAs reduced major adverse cardiovascular events by 21% (RR 0.79) compared to placebo
  • Reduced non-fatal myocardial infarction by 25% (RR 0.75)
  • No significant impact on cardiovascular mortality (RR 0.86) or non-fatal stroke (RR 0.91)
  • Increased risks of gastrointestinal adverse effects like diarrhea (RR 2.33) and nausea (RR 2.94)

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69c37be2b34aaaeb1a67ec66https://doi.org/10.2147/dmso.s580095
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