Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Why the study?
Does Vitamin E or pioglitazone improve outcomes in adults without diabetes with nonalcoholic steatohepatitis?
Population
Adults without diabetes with nonalcoholic steatohepatitis
Comparison
Vitamin E or pioglitazone vs Placebo
Design
RCT
Authors
Discussion
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Member takes
Implication
Supports vitamin E for non-diabetic NASH; confirms histologic benefit while challenging pioglitazone on primary outcome.
Structured PICO
Does Vitamin E or pioglitazone improve outcomes in adults without diabetes with nonalcoholic steatohepatitis?
P
Population
Adults without diabetes with nonalcoholic steatohepatitis
I
Intervention
Vitamin E or pioglitazone
C
Comparator
Placebo
O
Outcome
Treatment of nonalcoholic steatohepatitis (exact primary endpoint not specified in text)
Vitamin E is superior to placebo for treating nonalcoholic steatohepatitis in adults without diabetes, whereas pioglitazone does not significantly improve the primary outcome.
Cite This Study
Sanyal et al. (2010) studied this question.