Does Vitamin E or pioglitazone improve outcomes in adults without diabetes with nonalcoholic steatohepatitis?
Vitamin E is superior to placebo for treating nonalcoholic steatohepatitis in adults without diabetes, whereas pioglitazone does not significantly improve the primary outcome.
Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes. There was no benefit of pioglitazone over placebo for the primary outcome; however, significant benefits of pioglitazone were observed for some of the secondary outcomes. (ClinicalTrials.gov number, NCT00063622.)
Sanyal et al. (Wed,) studied this question.