Clinical and Reader Associated Correlates of Clinically Significant MRI-Invisible Prostate Cancer based on Negative MRI

Marina Schnauss; Nicole Handa; Ramin Nateghi; Ridwan Alam; Jae Woong Jang; Mitchell M. Huang; Aaron Abrams; Clayton Neill; Sai Kaushik Shankar Ramesh Kumar; Nikki Hubbard; Emma McGarrity; Yutai Li; Adam B. Murphy; Ulas Bagci; Anugayathri Jawahar; L. A. Cooper; Ashley E. Ross; Hiten  D. Patel

doi:10.1097/ju.0000000000005028

Key Points

This research aims to identify clinical predictors of clinically significant prostate cancer in patients with negative MRI scans.
Analyzed clinical data of patients with negative multiparametric MRI (mpMRI) for prostate cancer.
Assessed factors like MRI findings, symptoms, and radiologist experience to distinguish false negative and true positive cases.
Evaluated the impact of these predictors on biopsy decision-making.
MRI findings of benign prostatic hyperplasia (BPH) and prostatitis were notable in differentiating cases.
Lower radiologist read volume was associated with false negative results.
Enhanced stratification tools could increase confidence in avoiding biopsies for negative mpMRI.

Implication

Clinical findings differentiate significant prostate cancer in patients with negative MRI, suggesting improved diagnosis methods.

Abstract

Clinical predictors of csPCa remain similar among patients with negative mpMRI. MRI BPH and prostatitis along with lower radiologist read volume differentiated FN from TP cases. Enhanced clinical stratification tools and mpMRI refinements could improve confidence in forgoing biopsy for patients with a negative mpMRI.

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Cite This Study

Schnauss et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc02fdc3bde448917646 https://doi.org/10.1097/ju.0000000000005028

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Clinical and Reader Associated Correlates of Clinically Significant MRI-Invisible Prostate Cancer based on Negative MRI

Key Points

Implication

Abstract

Discussion

Cite This Study

Clinical and Reader Associated Correlates of Clinically Significant MRI-Invisible Prostate Cancer based on Negative MRI

Key Points

Implication

Abstract

Discussion

Cite This Study

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