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Review highlights the impact of reactive metabolite post-translational modifications on protein function, suggesting novel insights for cellular homeostasis.
Post-translational modifications (PTMs) include the addition of functional chemical groups, representing a crucial biochemical process that occurs after or during the synthesis of proteins, considerably impacting protein function, stability, localization, and interaction. In this ToxWatch, we review reactive metabolite PTMs as presented at the Fall 2025 American Chemical Society Meeting as part of the symposium entitled: Reactive Metabolite Post-Translational Modifications and Their Analysis.
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Gurajala et al. (2026) studied this question.
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