What question did this study set out to answer?

The research aims to evaluate the safety of intravenous chlorpromazine for treating hyperactive delirium in infants recovering from cardiac surgery.

1208: Safety of Chlorpromazine for Treating Delirium in Patients Recovering From Pediatric Cardiac Surgery

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Retrospective cohort study evaluates chlorpromazine safety for delirium in infants post-cardiac surgery, suggesting it is a viable treatment option.

The research aims to evaluate the safety of intravenous chlorpromazine for treating hyperactive delirium in infants recovering from cardiac surgery.
Conducted a single-center retrospective cohort study
Included patients less than 365 days old who underwent cardiac surgery in 2024
Administered IV chlorpromazine within 7 days post-surgery
Compared hemodynamic data before and after chlorpromazine exposure using paired t-tests
Measured Cornell Assessment of Delirium scores before and after chlorpromazine doses
Reviewed 30 patients who received 59 doses of chlorpromazine
Vasoactive-inotropic score significantly decreased after chlorpromazine (p=0.049)
CAPD scores significantly decreased post-treatment (p=0.005)
No new arrhythmias, seizures, or extrapyramidal symptoms reported
All patients survived to hospital discharge

Gerges et al. (2026) studied this question.

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Retrospective cohort study evaluates chlorpromazine safety for delirium in infants post-cardiac surgery, suggesting it is a viable treatment option.