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March 26, 2026Human Reproduction

Heat exposure during susceptible windows of spermatogenesis and sperm epigenetic age

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Authors

CNCarrie J. NoblesTCTimothy P CantyPMPauline Mendola

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Overview

Cohort study reveals heat stress accelerates sperm epigenetic age in men, suggesting risks for reproductive health.

Key Points

  • This research aims to determine how preconception heat exposure affects sperm epigenetic age during key spermatogenic phases.
  • Evaluated 1,220 men from an infertility treatment population
  • Calculated sperm epigenetic age from semen samples collected 6 months post-enrollment
  • Analyzed local hourly temperature data across specific spermatogenesis windows using generalized linear models
  • Each 10% increase in exposure to wet bulb temperatures ≥90th percentile accelerated sperm epigenetic age by 0.063 years
  • Strongest associations observed during meiosis I + II, with accelerations of 0.146 years at the ≥98th percentile
  • Associations with dry bulb temperatures were similar but less precise

Cite This Study

Nobles et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc69fdc3bde448917a91https://doi.org/10.1093/humrep/deag048
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