Key result
SOFA-2 outperforms SOFA-1 in predicting ICU mortality among critically ill patients.
Why the study?
Does the SOFA-2 score improve mortality prediction compared to SOFA-1 in critically ill patients?
Cohort (n=65,366)
No
Does the SOFA-2 score improve mortality prediction compared to SOFA-1 in critically ill patients?
Absolute Event Rate: 0.829% vs 0.796%
SOFA-2 provides superior discrimination over SOFA-1 for predicting ICU mortality in a high-acuity US cohort, supporting its broad applicability in critical care.
Supports SOFA-2 preference for ICU prognostication; extends validation to large contemporary US cohorts.
We validated the SOFA-2 score against the SOFA-1 score using 65,366 critically ill patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. SOFA-2 demonstrated superior discrimination for ICU mortality (AUROC: 0.829 [95% CI 0.823–0.835] vs. 0.796 [0.789–0.803]) and in-hospital mortality (0.789 [0.783–0.794] vs. 0.763 [0.757–0.769]) compared with SOFA-1. Of 65,366 patients, 40,990 (62.7%) were reclassified to higher scores under SOFA-2. Within each SOFA-1 stratum, those assigned higher SOFA-2 scores consistently demonstrated higher ICU mortality, confirming clinically meaningful reclassification. These findings provide additional external validation supporting the advantages of SOFA-2 for risk stratification in critically ill patients.
No takes yet. Share an insight, caveat, or question.
Bai et al. (2026) conducted a cohort in Critically ill patients (n=65,366). SOFA-2 vs. SOFA-1 was evaluated on ICU mortality (AUROC) (95% CI 0.823-0.835). SOFA-2 demonstrated superior discrimination for ICU mortality compared with SOFA-1 (AUROC 0.829 vs 0.796) in critically ill patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: