Longitudinal qMRI assessment reveals sensitive disease progression indicators in adults with spinal muscular atrophy, suggesting new evaluation methods.
This study provides the longest reported longitudinal qMRI assessment in adult SMA patients treated with nusinersen, demonstrating that mFF progressively increases despite stable clinical scores. The results suggest that qMRI may be a sensitive and objective biomarker for detecting subtle disease progression in adult SMA, potentially surpassing clinical measures.
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Mensch et al. (2026) studied this question.
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