Modeling tumor transport and growth with poroelastic biopolymer networks

Zecheng Li; Yifei Ren; Sharvari Kemkar; Paul Mollenkopf; Jakub Kochanowski; Paul A Janmey; Prashant Kishore Purohit; Ravi Radhakrishnan; Kyle H. Vining

doi:10.1039/d6sm00060f

January 1, 2026Soft MatterOpen Access

Modeling tumor transport and growth with poroelastic biopolymer networks

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Key Points

Examine how the mechanical properties of the extracellular matrix affect tumor growth and invasion.
Developed models based on poroelastic biopolymer networks
Analyzed the relationship between elasticity and tumor behavior
Investigated the role of extracellular matrix in tumor microenvironment dynamics
Demonstrated that increased elasticity enhances tumor growth
Found a correlation between biopolymer network structure and tumor invasion
Indicated that mechanical properties can influence therapeutic responses

Implication

Models explore the impact of mechanical properties on tumor growth in the tumor microenvironment, suggesting significant implications for treatment.

Abstract

The mechanical properties of the extracellular matrix (ECM) regulate tumor growth and invasion in the tumor microenvironment. Models of biopolymer networks have been used to investigate the impact of elasticity...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccaffdc3bde44891815b https://doi.org/10.1039/d6sm00060f

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Modeling tumor transport and growth with poroelastic biopolymer networks

Key Points

Implication

Abstract

Discussion

Cite This Study

Modeling tumor transport and growth with poroelastic biopolymer networks

Key Points

Implication

Abstract

Discussion

Cite This Study

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