The Association of a Positive Fecal Immunochemical Test With the Risk of Gastroesophageal Cancer: An Age‐Sex‐ H. Pylori Exposure Matched Cohort Study and Cost‐Effectiveness Analysis

ZOHAR LEVI; Naim Abu‐Freha; Doron Boltin; Maya Aharoni Golan; Tom Konikoff; Orly Sneh Arbib; Rachel Gingold Belfer; Sapir Eizenstein; Alex Vilkin; Shiri Kusnir; Adi Turgeman; Tanya Babich; Moshe Leshno; Anath Flugelman; Hadar Edelman‐Klapper; Elizabeth Half‐Onn

doi:10.1111/hel.70120

March 1, 2026HelicobacterOpen Access

The Association of a Positive Fecal Immunochemical Test With the Risk of Gastroesophageal Cancer: An Age‐Sex‐ H. Pylori Exposure Matched Cohort Study and Cost‐Effectiveness Analysis

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Key Points

The study aims to evaluate the risk of gastroesophageal cancer in individuals with a positive fecal immunochemical test.
Conducted a matched-cohort study comparing individuals with positive FIT and established high-risk groups.
Assessed the association of FIT results with gastroesophageal cancer incidence.
Performed a cost-effectiveness analysis for interventions using a one-time EGD alongside colonoscopy.
Individuals with a positive FIT exhibit an increased risk of gastroesophageal cancer.
The combination of EGD and colonoscopy is suggested as a cost-effective strategy for managing FIT-positive individuals.

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Implication

Matched-cohort study reveals increased GEC risk in individuals with positive FIT, suggesting cost-effective intervention strategies.

Abstract

This matched-cohort study suggests that individuals with a positive FIT may have an increased risk of GEC, comparable to that of established high-risk populations. Adding a one-time EGD to colonoscopy for FIT-positive individuals may be a cost-effective approach for healthcare systems that can accommodate such interventions.

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Cite This Study

LEVI et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccc9fdc3bde448918557 https://doi.org/10.1111/hel.70120

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The Association of a Positive Fecal Immunochemical Test With the Risk of Gastroesophageal Cancer: An Age‐Sex‐ H. Pylori Exposure Matched Cohort Study and Cost‐Effectiveness Analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

The Association of a Positive Fecal Immunochemical Test With the Risk of Gastroesophageal Cancer: An Age‐Sex‐ H. Pylori Exposure Matched Cohort Study and Cost‐Effectiveness Analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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