What question did this study set out to answer?

The study aims to develop a method for β-C-H functionalization of aliphatic ketones, esters, and acids using quinones.

March 26, 2026The Journal of Organic Chemistry

Free-Radical-Promoted β-C-H Functionalization of Simple Aliphatic Ketones, Esters, and Acids with Quinones

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Authors

JCJiaran Cao ZWZheng WangShihezi University YLYueyi LiShanghai Polytechnic University

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Implication

This research demonstrates a free-radical reaction that enables β-C-H functionalization in aliphatic carbonyl compounds, suggesting a novel synthetic strategy.

Key Points

The study aims to develop a method for β-C-H functionalization of aliphatic ketones, esters, and acids using quinones.
Introduced a free-radical-promoted coupling reaction
Targeted simple aliphatic ketones, esters, and acids
Avoided the use of exogenous directing groups and transition metals
Achieved site-selective β-C-H functionalization
Facilitated the formation of β-C-C bonds
Provided a new strategy for the selective alkylation of quinones

Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccc9fdc3bde4489185e3 https://doi.org/10.1021/acs.joc.5c03182

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Implication

This research demonstrates a free-radical reaction that enables β-C-H functionalization in aliphatic carbonyl compounds, suggesting a novel synthetic strategy.

Free-Radical-Promoted β-C-H Functionalization of Simple Aliphatic Ketones, Esters, and Acids with Quinones

Discussion

Member takes

Implication

Key Points

Cite This Study

Free-Radical-Promoted β-C-H Functionalization of Simple Aliphatic Ketones, Esters, and Acids with Quinones

Discussion

Member takes

Implication

Key Points

Cite This Study

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