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Heterogeneity and prognostic significance of mast cell subsets in the tumor microenvironment of prostate cancer

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Reveals mast cell subset heterogeneity influencing prognosis in prostate cancer, suggesting potential therapeutic targets.

The study aims to explore the diversity of mast cell subsets in the tumor microenvironment of prostate cancer and their prognostic relevance.
Analyzed single-cell and bulk RNA sequencing data from prostate cancer tumor samples.
Utilized non-negative matrix factorization to identify and cluster mast cell subsets.
Conducted survival analysis and ROC curve evaluation to determine prognostic value.
Identified two distinct mast cell subsets with unique gene markers and functions.
Mast cell1 correlated with pro-tumorigenic pathways, linked to poorer survival outcomes.
Mast cell2 showed antitumor properties, associated with better survival.
Key markers BIRC3 and FOS were identified as prognostic factors, with BIRC3 indicating unfavorable prognosis.

Fang et al. (2026) studied this question.

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