What question did this study set out to answer?

The aim is to develop effective inhibitors of Leishmania major by synthesizing novel imidazopyridine-isatin hybrids.

Synthesis and Biological Evaluation of Imidazopyridine-Isatin Hybrids as Inhibitors of Leishmania major Growth

View Full Paper

Ask AI

Bookmark

Authors

Sixteen novel compounds were evaluated for anti-leishmanial activity in vitro, suggesting new treatment options.

The aim is to develop effective inhibitors of Leishmania major by synthesizing novel imidazopyridine-isatin hybrids.
Designed 16 imidazopyridine-isatin hybrids with a hydrazide linker.
Evaluated anti-promastigote and anti-amastigote activities in vitro.
Assessed cytotoxicity and anti-folate mechanisms using folate-rescue assays.
Conducted molecular docking studies against Lm-PTR1.
Lead compound 5b demonstrated strong anti-promastigote activity (IC50 = 0.84 μM) and anti-amastigote activity (IC50 = 1.28 μM).
Compound 5b's activity could be reversed by folic and folinic acids, indicating an anti-folate mechanism.
The selectivity index for the most active compounds exceeded that of miltefosine, demonstrating better selectivity.
Molecular docking provided insights into the binding interactions and potential mechanism of action.

Hassab et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark