Electroreductive Cross-Electrophile Coupling of Polyfluoroarenes for the Synthesis of Polyfluoroarylmethanes and Polyfluorinated Biaryls

Yike Zhang; Shufei Zhu; Ling Fang; Chun Zhang; Dandan Hu; Jiacheng Wang; Jun‐Qi Zhang; Youai Qiu; Hongjun Ren

doi:10.1039/d5gc07014g

January 1, 2026Green Chemistry

Electroreductive Cross-Electrophile Coupling of Polyfluoroarenes for the Synthesis of Polyfluoroarylmethanes and Polyfluorinated Biaryls

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to develop a method for functionalizing polyfluoroarenes, addressing challenges related to C–F bond inertness.
Utilized electroreductive techniques for cross-electrophile coupling.
Applied reaction conditions suitable for incorporating polyfluoro groups.
Analyzed various reaction parameters to optimize yields.
Successfully synthesized polyfluoroarylmethanes from polyfluoroarenes.
Demonstrated that the method works under milder conditions compared to traditional approaches.
Achieved high yields of polyfluorinated biaryls, indicating a promising avenue for further research.

Implication

This research demonstrates efficient synthesis of polyfluoroarylmethanes in polyfluoroarenes, suggesting new chemical pathways.

Abstract

Polyfluoroarenes are essential motifs in pharmaceuticals, agrochemicals, and materials science, yet their direct functionalization remains challenging due to the high inertness of C–F bonds and the frequent requirement for harsh...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccf7fdc3bde448918ac7 https://doi.org/10.1039/d5gc07014g

View Full Paper

Ask AI

Bookmark

Share

Electroreductive Cross-Electrophile Coupling of Polyfluoroarenes for the Synthesis of Polyfluoroarylmethanes and Polyfluorinated Biaryls

Key Points

Implication

Abstract

Discussion

Cite This Study

Electroreductive Cross-Electrophile Coupling of Polyfluoroarenes for the Synthesis of Polyfluoroarylmethanes and Polyfluorinated Biaryls

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading