Observational research finds doxycycline post-exposure prophylaxis lowers chlamydia rates in certain groups, indicating its potential effectiveness.
In this real-world setting, DoxyPEP awareness and uptake were substantial and highest among cisgender men and PLWH. Current DoxyPEP use was associated with fewer chlamydia diagnoses, higher gonorrhea rates, and no clear benefit in syphilis prevention due to low numbers.
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Chan et al. (2026) studied this question.
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