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March 26, 2026BMC NeuroscienceOpen Access

Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice

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Authors

MFMichael FiorilloJGJavier González-Maeso

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Overview

Prophylactic DOI treatment mitigates hippocampal inflammation and behavioral impairments in mice, suggesting potential therapeutic applications.

Key Points

  • The study aims to determine if the psychedelic DOI can prevent neuroinflammation and related behavioral deficits in mice.
  • Wild-type and 5-HT2AR knockout mice were used.
  • Mice received LPS to induce neuroinflammation at different time points.
  • DOI was administered 24 hours prior to LPS challenge to assess prophylactic effects.
  • Cytokine levels were quantified via multiplex assays, and behavioral assays measured effects.
  • LPS treatment significantly increased IL-6 and TNF-α levels and caused behavioral deficits.
  • DOI pretreatment reduced inflammatory cytokines and improved locomotor and behavioral outcomes.
  • 5-HT2AR-KO mice showed heightened cytokine responses suggesting partial receptor independence.
  • Correlation between cytokine levels and behavior indicates a link between inflammation and depressive-like symptoms.

Cite This Study

Fiorillo et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd25fdc3bde448919107https://doi.org/10.1186/s12868-026-01003-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress2024 · 3 citations
  2. 2Microglia-dependent LPS preconditioning prevents neuroinflammation-induced behavioral deficits in male mice2025
  3. 3Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?2025
  4. 4Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation2024
  5. 5The Effect of Acute and Chronic Administration of Fluoxetine on R−(−)− DOI Induced Head Twitch Response in Swiss-Webster Mice2024