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October 13, 2025Open Access

Microglia-dependent LPS preconditioning prevents neuroinflammation-induced behavioral deficits in male mice

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Authors

MKMinori KogaHNHiroyuki NakashimaMSMasafumi Saito

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Overview

Experimental study shows that LPS preconditioning prevents behavioral deficits in male mice, indicating microglial involvement.

Key Points

  • LPS preconditioning prevents social preference deficits caused by inflammation in male mice, improving behavioral outcomes.
  • The preference score improved significantly from -0.49 to 0.14, highlighting protective effects of microglial preconditioning.
  • Intervention involved preconditioning with LPS, followed by behavioral assessment post inflammation exposure in male mice.
  • Findings support the concept that microglial preconditioning may inform treatments for neuroinflammatory-related psychiatric disorders.

Cite This Study

Koga et al. (2025) studied this question.

synapsesocial.com/papers/68ec51df42911f61ef8b20d4https://doi.org/10.1101/2025.10.10.681580
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