What question did this study set out to answer?

The aim is to evaluate the diagnostic accuracy and clinical impact of FDG PET/CT in various infectious conditions.

March 26, 2026The Quarterly Journal of Nuclear Medicine and Molecular Imaging

[18F]FDG PET/CT in fever and inflammation of unknown origin, bacteremia, and sepsis: an umbrella review of diagnostic accuracy and clinical impact

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The aim is to evaluate the diagnostic accuracy and clinical impact of FDG PET/CT in various infectious conditions.
Conducted an umbrella review of systematic reviews analyzing the use of FDG PET/CT.
Focused on conditions such as fever of unknown origin, bacteremia, and sepsis.
Assessed diagnostic accuracy and clinical management outcomes based on existing literature.
FDG PET/CT proved to be a valuable tool in diagnosing fever of unknown origin and related infections.
Enhanced patient management strategies were demonstrated through its implementation.
The review suggests a need for standardized imaging protocols to optimize diagnostic effectiveness.

Implication

An umbrella review reveals FDG PET/CT improves diagnosis in fever and infection conditions, indicating its clinical significance.

Abstract

Evidence from systematic reviews demonstrates that [¹⁸F]FDG PET/CT is a valuable diagnostic tool in FUO/IUO, bacteremia, sepsis, and related infectious/inflammatory conditions, with clinically significant impact on patient management. Strategic patient selection based on clinical risk factors optimizes cost-effectiveness. Future standardization of imaging protocols and prospective comparative studies are needed to define optimal clinical indications across different populations.

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Cite This Study

Martinello et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd49fdc3bde44891971e https://doi.org/10.23736/s1824-4785.26.03717-9

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Implication

An umbrella review reveals FDG PET/CT improves diagnosis in fever and infection conditions, indicating its clinical significance.

[18F]FDG PET/CT in fever and inflammation of unknown origin, bacteremia, and sepsis: an umbrella review of diagnostic accuracy and clinical impact

Key Points

Implication

Abstract

Discussion

Cite This Study

[18F]FDG PET/CT in fever and inflammation of unknown origin, bacteremia, and sepsis: an umbrella review of diagnostic accuracy and clinical impact

Key Points

Implication

Abstract

Discussion

Cite This Study

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