Key result
Anticoagulation resolves multiorgan thromboembolism in a pediatric RCM case with prothrombotic variants despite sinus rhythm.
Case Report (n=1)
No
This case highlights the severe risk of recurrent systemic thromboembolism in pediatric restrictive cardiomyopathy even in the absence of atrial fibrillation, emphasizing the need for early prophylactic anticoagulation.
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May warrant prophylactic anticoagulation in pediatric restrictive cardiomyopathy despite sinus rhythm; extends risk beyond AF and is hypothesis-generating.
Restrictive cardiomyopathy is a rare paediatric myocardial disorder causing diastolic dysfunction with preserved systolic function. We report a 14-year-old girl with idiopathic restrictive cardiomyopathy and recurrent systemic thromboemboli (stroke, limb ischaemia, renal infarction, and intracardiac thrombi) despite sinus rhythm. Anticoagulation resolved thrombi. She is currently awaiting heart transplantation. Early recognition, prompt anticoagulation, genetic evaluation, and consideration for transplantation are essential to optimise outcomes.
Kurt et al. (2026) conducted a case report in Paediatric restrictive cardiomyopathy (n=1). Anticoagulation (warfarin, low-molecular-weight heparin, tissue plasminogen activator) was evaluated on Resolution of intracardiac thrombi and improved perfusion. Anticoagulation resolved recurrent multiorgan thromboembolism in a 14-year-old girl with idiopathic restrictive cardiomyopathy and prothrombotic genetic variants despite maintained sinus rhythm.
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