Green synthesis of a 4-hydroxydithiocoumarin-imidazole bis-heterocycle scaffold, and its antiproliferative study and unusual single-crystal XRD pattern

Catalyst-free synthesis of novel tetra -substituted imidazole-bound bis-heterocycles via a pseudo-five-component reaction. Using 4-hydroxydithiocoumarin, isocyanide, ammonium acetate, and aryl aldehydes forms multiple C–C and C–N bonds in one step.