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This research aims to develop an efficient and sustainable method for synthesizing highly functionalized pyrano-pyrazole derivatives.

Cascade‐Based Synthesis of Highly Functionalized Pyrano2,3 ‐c pyrazole Derivatives Using a Metal‐Free Catalyst in Green Solvent

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Efficient protocol synthesizes functionalized pyrano-pyrazole derivatives in green solvents, indicating sustainable methods.

This research aims to develop an efficient and sustainable method for synthesizing highly functionalized pyrano-pyrazole derivatives.
Utilized ethyl acetoacetate, hydrazine hydrate, malononitrile, and arylaldehydes.
Employed a catalytic amount of DBN in a mixture of ethanol and water.
Conducted the reaction under mild conditions to align with green chemistry principles.
Achieved yields ranging from 85% to 95% for the synthesized compounds.
Demonstrated the potential antioxidant activity of the synthesized derivatives.

Yadav et al. (2026) studied this question.

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