Demonstrates updated insights into MS genetics, highlighting distinct disease mechanisms and future applications.
Advances in genetics are broadening the conceptual framework of MS pathogenesis, separating the immunological triggers of disease susceptibility from distinct, CNS-specific drivers of disease progression. Future efforts leveraging longitudinal, deeply phenotyped cohorts and functional validations will empower translational applications for prevention, prognostication, and treatment.
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Bellucci et al. (2026) studied this question.
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