A two-step ozonolysis method synthesizes sclareolide from sclareol, indicating an efficient chemical process.
A two-step ozonolysis method was developed for synthesizing sclareolide from sclareol. By regulating the pH value in the first step, the two oxidation stages were effectively separated and their conditions were optimized, affording the product in 70% overall yield. This route demonstrates good atom economy and avoids the use of noble metal catalysts.
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Zhang et al. (2026) studied this question.
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