What question did this study set out to answer?

This research examines how the excitability of cortical neurons influences the organization of their striatal projections.

March 26, 2026Proceedings of the National Academy of SciencesOpen Access

Biologically grounded on-chip model identifies selective topographic reorganization within hyperexcitable corticostriatal networks

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Authors

MPMaxime PoinsotCentre National de la Recherche Scientifique MSMarc Dos SantosNorthwestern University BMBaptiste Marthy

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Implication

Biologically grounded model shows disrupted connectivity in hyperexcitable corticostriatal networks, suggesting implications for neurodevelopmental disorders.

Key Points

This research examines how the excitability of cortical neurons influences the organization of their striatal projections.
Engineered a biologically faithful in vitro model inspired by the Tesla valve.
Controlled excitability regimes to observe impacts on neighboring corticostriatal territories.
Monitored axonal growth transitions and territorial dynamics during development.
Cortical hyperexcitability disrupted normal axonal growth and stabilization patterns.
Ectopic convergence zones formed leading to loss of segregation between parallel pathways.
Local connectivity patterns remained unaffected despite long-range disruption.

Cite This Study

Poinsot et al. (2026) studied this question.

synapsesocial.com/papers/69c4cddcfdc3bde44891aad2 https://doi.org/10.1073/pnas.2513459123

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Implication

Biologically grounded model shows disrupted connectivity in hyperexcitable corticostriatal networks, suggesting implications for neurodevelopmental disorders.

Biologically grounded on-chip model identifies selective topographic reorganization within hyperexcitable corticostriatal networks

Discussion

Member takes

Implication

Key Points

Cite This Study

Biologically grounded on-chip model identifies selective topographic reorganization within hyperexcitable corticostriatal networks

Discussion

Member takes

Implication

Key Points

Cite This Study

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