Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

Nuri Han; Tom Loosli; Mamatha Sauermann; İpek Çelikağ; Nanina Anderegg; Bertha Cinthia Baye; Carolyn Bolton‐Moore; Lydia Buzaalirwa; Helen Byakwaga; Cleophas Chimbetete; Peter Vanes Ebasone; S. Goodrich; Jacqueline Huwa; Charles Kasozi; Adolphe Mafoua; A C Massamba; Eugène Messou; Albert Minga; Gad Murenzi; Guy Muula; Winnie Muyindike; Shirelle Janine Naidoo; Dominique Mahambou Nsonde; Armel G Poda; Richard Ramdé; Aggrey Semeere; Lavanya Singh; Huldrych F Günthard; Matthias Egger; Jennifer Giandhari; Richard Lessells; Roger D. Kouyos

doi:10.1093/jac/dkag088

Key Points

This research aims to explore novel mutations linked to dolutegravir resistance in African non-B HIV-1 strains.
Identified amino acid substitutions associated with dolutegravir resistance.
Analyzed genetic variations outside established drug resistance mutations (DRMs).
Utilized the DTG RESIST cohort for data collection.
Several novel amino acid substitutions were linked to dolutegravir resistance.
Mutations identified lay outside the currently classified drug resistance mutations.
The findings highlight the complexity of dolutegravir resistance evolution.

Implication

Novel integrase mutations indicate predicted dolutegravir resistance in non-B HIV-1 strains, suggesting complexity in resistance evolution.

Abstract

We identified several amino acid substitutions outside the established DRMs that are strongly associated with predicted dolutegravir resistance. Dolutegravir resistance evolution is complex and likely involves mutations not currently classified as DRMs.

Discussion

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Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/69c4cec3fdc3bde44891ab89 https://doi.org/10.1093/jac/dkag088

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Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

Key Points

Implication

Abstract

Discussion

Cite This Study

Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

Key Points

Implication

Abstract

Discussion

Cite This Study

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