Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

Key Points

• This research aims to explore novel mutations linked to dolutegravir resistance in African non-B HIV-1 strains.
• Identified amino acid substitutions associated with dolutegravir resistance.
• Analyzed genetic variations outside established drug resistance mutations (DRMs).
• Utilized the DTG RESIST cohort for data collection.
• Several novel amino acid substitutions were linked to dolutegravir resistance.
• Mutations identified lay outside the currently classified drug resistance mutations.
• The findings highlight the complexity of dolutegravir resistance evolution.