Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis

Matthias Briel; Ignacio Ferreira‐González; John J. You; P. J Karanicolas; Elie Akl; Ping Wu; Boris Blechacz; Dirk Bassler; Wei Xiao; Asheer Sharman; Irene Whitt; S. Alves da Silva; Zara Khalid; Alain Nordmann; Qi Zhou; Stephen D. Walter; Noah Vale; Neera Bhatnagar; C. O’Regan; Edward J. Mills; Heiner C. Bucher; Víctor M. Montori; Gordon Guyatt

doi:10.1136/bmj.b92

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Abstract

Available data suggest that simply increasing the amount of circulating high density lipoprotein cholesterol does not reduce the risk of coronary heart disease events, coronary heart disease deaths, or total deaths. The results support reduction in low density lipoprotein cholesterol as the primary goal for lipid modifying interventions.

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Briel et al. (2009) studied this question.

synapsesocial.com/papers/69c583ae3a245b5aa6c36e4c https://doi.org/10.1136/bmj.b92

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Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis

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Abstract

Discussion

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Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis

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Abstract

Discussion

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