What question did this study set out to answer?

The aim is to develop 3D-printed scaffolds incorporating gallic acid to enhance bioactivity and antibacterial properties for bone tissue engineering.

March 27, 2026ChemBioChem

Bioactive and Antibacterial Gallic Acid Incorporated 3D‐Printed Hydroxyapatite/Gelatin/Carboxymethyl Cellulose Scaffolds for Bone Tissue Engineering

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Authors

AGAlper GüvenBoğaziçi University SİSezgi İyigünBoğaziçi University ETEmrah TorlakNecmettin Erbakan University

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Implication

Demonstrates improved mechanical properties and antibacterial activity in bone scaffolds, suggesting their potential application in tissue engineering.

Key Points

The aim is to develop 3D-printed scaffolds incorporating gallic acid to enhance bioactivity and antibacterial properties for bone tissue engineering.
Developed scaffolds using 3D printing with gallic acid, hydroxyapatite, carboxymethyl cellulose, and gelatin.
Conducted rheological studies and cross-linked scaffolds with carbodiimide hydrochloride.
Performed mechanical testing and evaluated cytocompatibility with MC3T3-E1 pre-osteoblasts.
Analyzed antibacterial effects against Escherichia coli and Staphylococcus aureus.
Scaffolds demonstrated increased compressive strength and ductility with gallic acid incorporation.
Observed apatite-forming ability in simulated body fluid.
Significant reduction in bacterial viability: 62.0% for Escherichia coli and 78.1% for Staphylococcus aureus.
Increased metabolic activity in pre-osteoblasts on GA-containing scaffolds, despite reduced mineralization.

Cite This Study

Güven et al. (2026) studied this question.

synapsesocial.com/papers/69c61fa915a0a509bde1822b https://doi.org/10.1002/cbic.202500922

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Implication

Demonstrates improved mechanical properties and antibacterial activity in bone scaffolds, suggesting their potential application in tissue engineering.

Bioactive and Antibacterial Gallic Acid Incorporated 3D‐Printed Hydroxyapatite/Gelatin/Carboxymethyl Cellulose Scaffolds for Bone Tissue Engineering

Discussion

Member takes

Implication

Key Points

Cite This Study

Bioactive and Antibacterial Gallic Acid Incorporated 3D‐Printed Hydroxyapatite/Gelatin/Carboxymethyl Cellulose Scaffolds for Bone Tissue Engineering

Discussion

Member takes

Implication

Key Points

Cite This Study

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