Insertion of SnCl₂ into the Pd–Cl Bond: Mechanistic Elucidation and Antitumor Evaluation of Trichlorostannyl Palladium-NHC Allyl Complexes in Ovarian Cancer Models

Eleonora Botter; Valentina Lauteri; Alessandro Rubbi; Laura Orian; Matteo Forner; Valentina Gandin; Nicola Demitri; Vincenzo Canzonieri; Flavio Rizzolio; Enrico Cavarzerani; Fabiano Visentin; Thomas Scattolin

doi:10.1039/d6dt00680a

January 1, 2026Dalton TransactionsOpen Access

Insertion of SnCl₂ into the Pd–Cl Bond: Mechanistic Elucidation and Antitumor Evaluation of Trichlorostannyl Palladium-NHC Allyl Complexes in Ovarian Cancer Models

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Key Points

The research aims to investigate new metal-based treatments for ovarian cancer, particularly targeting platinum resistance.
Designed and synthesized trichlorostannyl palladium-NHC allyl complexes.
Evaluated antitumor effects in ovarian cancer models.
Conducted mechanistic studies to understand interactions with tumor cells.
Identified effective antitumor activity against ovarian cancer cell lines.
Demonstrated potential to overcome platinum resistance.
Uncovered details of the mechanistic pathways involved in the treatment.

Implication

This investigation reveals antitumor effects of metal-based complexes in ovarian cancer, suggesting potential therapeutic advancements.

Abstract

The development of effective and selective metal-based chemotherapeutics remains a central challenge in ovarian cancer treatment, particularly in addressing resistance to platinum agents. Herein, we report the design, synthesis, and...

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Cite This Study

Botter et al. (2026) studied this question.

synapsesocial.com/papers/69c61fd715a0a509bde182ec https://doi.org/10.1039/d6dt00680a

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Insertion of SnCl₂ into the Pd–Cl Bond: Mechanistic Elucidation and Antitumor Evaluation of Trichlorostannyl Palladium-NHC Allyl Complexes in Ovarian Cancer Models

Key Points

Implication

Abstract

Discussion

Cite This Study

Insertion of SnCl₂ into the Pd–Cl Bond: Mechanistic Elucidation and Antitumor Evaluation of Trichlorostannyl Palladium-NHC Allyl Complexes in Ovarian Cancer Models

Key Points

Implication

Abstract

Discussion

Cite This Study

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