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March 27, 2026Journal of Indira Gandhi Institute Of Medical SciencesOpen Access

From predictive association to decision-grade deployment: Refining the clinical role of urinary neutrophil gelatinase-associated lipocalin in acute kidney injury

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Authors

MVM VijayasimhaChandigarh UniversityMSMulavagili SrikanthPandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

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Implication

Cohort study explores urinary neutrophil gelatinase-associated lipocalin's role in predicting acute kidney injury, suggesting enhanced clinical utility.

Key Points

  • To assess urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a decision-support tool in predicting acute kidney injury (AKI).
  • Conducted a prospective cohort study
  • Utilized composite endpoint of in-hospital mortality and renal replacement therapy (RRT)
  • Measured uNGAL levels and correlated with clinical outcomes
  • Evaluated timing and variability in uNGAL testing
  • uNGAL serves as an early indicator of tubular injury
  • Composite endpoints need careful interpretation
  • Timing and rate of uNGAL changes influence clinical outcomes
  • Need for standardized reporting and clinical validation of uNGAL implementation

Cite This Study

Vijayasimha et al. (2026) studied this question.

synapsesocial.com/papers/69c61fd715a0a509bde184d2https://doi.org/10.4103/jigims.jigims_90_25
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