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March 27, 2026Organic & Biomolecular Chemistry1 citations

Rh(III)-Catalyzed Cascade C-H Activation/Amination Enables the Synthesis of 1,2-Disubstituted Benzimidazoles from Amidines and Arynes

FXFen XuSZShiyu ZhangJHJia-Qi Huo

Key Points

  • This research aims to develop an efficient method for synthesizing 1,2-disubstituted benzimidazoles using Rh(III) catalysis.
  • Conducted cascade C-H activation and amination reactions
  • Utilized amidines and arynes as substrates
  • Employed rhodium (Rh) as the catalyst
  • Successfully synthesized 1,2-disubstituted benzimidazoles
  • Demonstrated high efficiency in the reaction process
  • Provided a new pathway for benzimidazole synthesis

Abstract

Benzimidazoles are versatile and indispensable scaffolds widely used in organic synthesis. Herein, we report a Rh(III)-catalyzed cascade C-H activation/amination reactions between amidines and arynes, enabling the efficient synthesis of 1,2-disubstituted...

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69c61ff615a0a509bde186a8https://doi.org/10.1039/d6ob00074f
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