The research demonstrates a copper-promoted coupling method for integrating dithiocarbamates into DNA libraries, suggesting a new tool for drug discovery.
To enable the efficient incorporation of S-aryl dithiocarbamates into DNA-encoded libraries (DELs), we have developed a robust, sequential three-component copper-promoted C(sp2)–S coupling reaction. This protocol employs DNA-conjugated secondary amines, carbon disulfide (CS2), and commercially available aryl boronic acids as readily accessible substrates, affording structurally diverse DNA-conjugated S-aryl dithiocarbamates, motifs that constitute privileged scaffolds in medicinal chemistry and are recurrent in bioactive compounds.
No takes yet. Share an insight, caveat, or question.
Jing et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: