Demonstrates high-yield synthesis of N-sulfonylguanidines in DNA-encoded libraries, indicating promising applications in drug discovery.
To incorporate the N -sulfonylguanidine chemotype into DNA-encoded libraries (DELs), a cobalt-promoted, DNA-compatible N -sulfonylguanidine formation method has been developed. This method utilizes DNA-conjugated sulfonyl azides, isonitriles, and amines as readily accessible building blocks to enable modular, high-yielding synthesis of structurally diverse N -sulfonylguanidines, a privileged scaffold widely represented in biologically active small molecules.
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Yao et al. (2026) studied this question.
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