Experimental study demonstrates cobalt(II)-catalyzed multicomponent coupling to synthesize sulfoximine guanidines, indicating broad functional group tolerance without motif degradation.
We have developed a cobalt(II)-catalyzed three-component coupling of sulfoximines, isocyanides, and sulfonyl azides for the synthesis of sulfoximine-containing guanidines. The method features operational simplicity, broad substrate applicability, and good functional group tolerance. In this work, “protection” refers to retention of the high-valent S(VI) sulfoximine motif during guanidine construction rather than introduction of a conventional removable protecting group.
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Ding et al. (2026) studied this question.
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