Co-Cu bimetallic MOF-derived nanozyme-based colorimetric immunoassay with smartphone-based RGB readout for sensitive detection of alpha-fetoprotein

Shengyi Fang; Sheng Ye; Dan Ouyang; Songyan Tie; Jianzhong Cao

doi:10.1039/d6ay00326e

January 1, 2026Analytical Methods

Co-Cu bimetallic MOF-derived nanozyme-based colorimetric immunoassay with smartphone-based RGB readout for sensitive detection of alpha-fetoprotein

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Key Points

This research aims to enhance catalytic activity in nanozymes for improved detection of alpha-fetoprotein using a colorimetric immunoassay.
Developed a bimetallic Cu-Co nanozyme from metal-organic frameworks
Implemented a colorimetric detection method using RGB readings from smartphones
Designed the study to assess sensitivity and specificity for alpha-fetoprotein detection.
Achieved enhanced detection sensitivity compared to traditional methods
Demonstrated a clear color change correlating to alpha-fetoprotein concentrations
Provided a user-friendly readout via smartphone technology.

Implication

Colorimetric immunoassay detects alpha-fetoprotein in serum, indicating a novel diagnostic approach.

Abstract

Nanocatalysts based on metal-organic frameworks exhibit limited catalytic activity due to their symmetrical inactive structures, thereby restricting their application in nanozyme-linked immunoassays (NLISA). This work constructed geometrically structure expanded Cu-Co...

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Cite This Study

Fang et al. (2026) studied this question.

synapsesocial.com/papers/69c6201515a0a509bde1870e https://doi.org/10.1039/d6ay00326e

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Co-Cu bimetallic MOF-derived nanozyme-based colorimetric immunoassay with smartphone-based RGB readout for sensitive detection of alpha-fetoprotein

Key Points

Implication

Abstract

Discussion

Cite This Study

Co-Cu bimetallic MOF-derived nanozyme-based colorimetric immunoassay with smartphone-based RGB readout for sensitive detection of alpha-fetoprotein

Key Points

Implication

Abstract

Discussion

Cite This Study

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