Random Sequence-Guided Crosslinking for On-Demand Injectable HA-DNA Hydrogels Supporting Neural Progenitor Cells

Q: What does this research mean for the field?

Random sequence-guided crosslinking enables the creation of on-demand injectable HA-DNA hydrogels that prevent premature network formation while supporting neural progenitor cells. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Taehyun Kim; Eunseo Han; Siyeon Park; Jieung Baek

doi:10.1039/d5nr05011a

January 1, 2026NanoscaleOpen Access

Random Sequence-Guided Crosslinking for On-Demand Injectable HA-DNA Hydrogels Supporting Neural Progenitor Cells

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Key Points

To explore a method for creating on-demand injectable hydrogels using hyaluronic acid and DNA.
Developed a crosslinking technique using DNA hybridization to create hydrogels.
Evaluated the compatibility of hydrogels with neural progenitor cells.
Assessed the impact of the hydrogels on cell behavior and network formation.
The hydrogels maintained cell viability and supported neural progenitor cell growth.
Controlled network formation improved upon previous methods of hydrogel creation.

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Implication

This research demonstrates the creation of injectable HA-DNA hydrogels to support neural progenitor cells, suggesting new applications in regenerative medicine.

Abstract

Hyaluronic acid (HA) hydrogels crosslinked through DNA hybridization (HA-DNA) offer a programmable and cell-compatible platform for regenerative medicine. However, their practical use has been limited by undesired premature network formation...

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69c6204c15a0a509bde18c05 https://doi.org/10.1039/d5nr05011a

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Random Sequence-Guided Crosslinking for On-Demand Injectable HA-DNA Hydrogels Supporting Neural Progenitor Cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Random Sequence-Guided Crosslinking for On-Demand Injectable HA-DNA Hydrogels Supporting Neural Progenitor Cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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