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March 27, 2026GigaScienceOpen Access

Dissecting glioblastoma risk signatures in the tumor immune microenvironment based on multi-dimensional transcriptomics

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Authors

TLTengyue LiHarbin Medical UniversityWMWanqi MiHarbin Medical UniversityHYHuarui YanNorth China Electric Power University

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Implication

Analysis uncovers prognostic signatures in glioblastoma, suggesting pathways for improved survival outcomes.

Key Points

  • The aim is to analyze the tumor immune microenvironment in glioblastoma to identify prognostic signatures and their molecular mechanisms.
  • Integrated analysis of single-cell, bulk, and spatial transcriptomic data
  • Identification of prognostic signatures using a machine learning algorithm
  • Conducted ligand-receptor interaction analysis to explore gene interactions
  • Evaluated immune checkpoint gene expression along T-cell differentiation trajectories
  • Performed SHAP analysis to validate predictive importance of identified signatures.
  • Identified seven hallmark-related prognostic signatures associated with glioblastoma survival
  • Delineated poor prognosis linked to OPHN1 interactions
  • Upregulation of immune checkpoint genes LAG3, PDCD1, and HAVCR2 during T-cell differentiation
  • Demonstrated synergistic gene interactions influencing patient survival within the tumor microenvironment

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c6206115a0a509bde18d76https://doi.org/10.1093/gigascience/giag035
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potential Prognostic Markers for Glioblastoma Associated with the Glioma Immune Microenvironment2025 · 2 citations
  2. 2TMIC-63. Microenvironment archetypes in 1,979 glioblastomas reveal cell state-specific drivers of immune recruitment and survival benefit2025
  3. 3Immune-related hallmark pathway heterogeneity identifies a prognostic risk signature with independent external validation in glioblastoma2026
  4. 4Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma2024 · 1 citations
  5. 5Deciphering the glioblastoma microenvironmental landscape with multi-modal radiogenomics to guide prognosis and personalized therapy2026 · 1 citations