Amygdala transcranial ultrasound stimulation disrupts threat acquisition and extinction learning

Gregory A. Fonzo; Kevin S. LaBar

doi:10.1126/sciadv.aeg8830

March 25, 2026Science AdvancesOpen Access

Amygdala transcranial ultrasound stimulation disrupts threat acquisition and extinction learning

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Key Points

To examine how transcranial ultrasound stimulation affects threat acquisition and extinction learning phases in humans.
Applied transcranial ultrasound stimulation to the amygdala.
Assessed the impact on threat learning and extinction processes.
Transcranial ultrasound led to disruptions in initial threat learning phases.
Extricated the effects on subsequent extinction learning.

Implication

Transcranial ultrasound stimulation disrupts threat learning and extinction in humans, suggesting novel intervention pathways.

Abstract

Transcranial ultrasound stimulation applied to the human amygdala selectively impacts the initial phases of both threat learning and its subsequent extinction.

Discussion

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Cite This Study

Fonzo et al. (2026) studied this question.

synapsesocial.com/papers/69c6206115a0a509bde18e14 https://doi.org/10.1126/sciadv.aeg8830

View Full Paper

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Amygdala transcranial ultrasound stimulation disrupts threat acquisition and extinction learning

Key Points

Implication

Abstract

Discussion

Cite This Study

Amygdala transcranial ultrasound stimulation disrupts threat acquisition and extinction learning

Key Points

Implication

Abstract

Discussion

Cite This Study

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